How To Increase Akkermansia A Comprehensive information

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Digestion, immune system regulation, healthy weight maintenance, and many other bodily functions rely on the complex community of bacteria, fungi, and viruses that make up the gut microbiome. One of the over 5,000 bacteria in the digestive tract is Akkermansia muciniphila.  Weirdnewsera that you might not find any other platform which gives you all content about health sports business technology and entertainment. 

What is Akkermansia? or How to increase Akkermansia?

Akkermansia muciniphila is an anaerobic (low-oxygen) gram-negative bacteria in the colon’s mucus layer. It is one of the most common bacteria in the gut microbiome, accounting for up to 5% of the total bacteria count in healthy adults’ digestive systems.

  • Akkermansia and the Digestive Tract Mucus: It thrives on the mucus layer’s glycoproteins (proteins covered in sugar molecules) and generates the short-chain fatty acids acetate and propionate as a waste product.
  • Connection to Leaky Gut: Akkermansia breaks down mucus, which prompts stem cells to differentiate into mucus-producing cells. Overall, Akkermansia has led to increased mucus production and strengthened mucus membranes.

What health benefits does Akkermansia provide?

The gut microbiome is a complex ecosystem containing trillions of bacteria, both beneficial and harmful.

When a person reaches adulthood, the microbiome in their digestive tract stabilizes and becomes more diverse. A healthy gut microbiome benefits overall health, but the opposite is true when the microbes in the gut are out of whack.

How does any of this relate to Akkermansia?

  • Epithelial cells (the cells that line the surfaces of organs) line the inside of your digestive tract. This mucus layer is rich in protein called mucin.
  • This mucin is a big hit with the akkermansia! Akkermansia gets its vitality from mucin, which it adores.

In his opinion, Akkermansia is comparable to the arcade game Pac-Man, as stated by Neuse. Consider that Akkermansia devotes its entire day to digesting the mucin in your body. It’s gross, but we’re hoping for this to take place.

  • When Akkermansia consumes mucin, it signals to the epithelial cells nearby to produce more mucin.
  • Your intestinal wall is significant to your health, and this additional “mucin making” is what does it.

The health and wellness industry took notice of Akkermansia muciniphila as soon as it became available for two main reasons:

  1. It was an extremely beneficial probiotic strain for intestinal health.
  2. A probiotic strain unique to Pendulum Glucose Control

Was it possible that there could be an “Akkermansia stand-alone pill?”

  • And now, in the present day, there is Pendulum Akkermansia.
  • A healthy ecosystem of beneficial bacteria in your gut microbiome is essential to your overall health, and Pendulum Akkermansia can help you achieve that. ⁵
  • Pendulum Akkermansia, when taken orally, restores gastrointestinal tract populations of Akkermansia muciniphila.
  • There are 6 milligrams of the probiotic Akkermansia muciniphila in each Pendulum Akkermansia capsule, fed by the tablet’s chicory inulin (prebiotic).
  • Pendulum Akkermansia is safe for once-daily use and can be kept at room temperature.
  • Pendulum Akkermansia, unlike Pendulum Glucose Control, is not meant to treat Type 2 diabetes.

How To Increase Akkermansia in the Gut? 

 Disease and Health related to Akkermansia

Akkermansia can be found in the digestive systems of both adults and infants.

How To Increase Akkermansia?It’s interesting to note that Akkermansia is present in both colostrum and breast milk. Babies who consume these probiotics at a young age will have a greater chance of developing a healthy gut microbiome.

  • Malady and Akkermansia: Akkermansia muciniphila is found in the guts of adults and is associated with a reduced risk of cardiovascular disease, obesity, type 2 diabetes, and chronic low-grade inflammation. Better glycemic control, lower serum lipid levels, and a decreased risk of appendicitis and inflammatory bowel disease have all been linked to Akkermansia.
  • Thicken Your Mucus Layer There is speculation that bolstering gut barriers via increased mucus layer thickness is practical. One reason is that Akkermansia can prevent the leaky gut syndrome it treats and the systemic inflammation it prevents by preventing endotoxin from other gut bacteria from crossing the gut barrier.
  • The term “leaky gut” refers to the phenomenon in which food antigens can pass through the intestinal lining and are then recognized as foreign by the immune system, triggering an allergic reaction. Significant implications for both conditions arise from Akkermansia’s ability to halt or reverse leaky gut. When intestinal permeability is low, antigen molecules cannot cross the mucosa and thus escape detection by the body’s defenses.

Akkermansia Dietary Strategies

Akkermansia populations gain an additional advantage from necessary prebiotics in addition to feeding on mucus proteins. Prebiotics are indigestible molecules that make it to the colon, where they can promote the growth of beneficial microbes. Some prebiotics, such as polyphenols and oligosaccharides in human milk, encourages the development of Akkermansia (HMOs).

if you are worried about your health and get more information about Akkermansia then you definitely click on this. Dietary strategies to promote the abundance of intestinal Akkermansia

Polyphenols

Polyphenols, a class of antioxidant molecules in many foods, are often easily identified by their vibrant hues. Anthocyanins, for instance, are present in foods like blueberries, blackberries, cranberries, and red cabbage, giving these fruits and vegetables their distinctively dark purple-blue color.

For this reason, polyphenols are often used to reduce the risk of oxidative stress and inflammation.

Polyphenols not only reduce inflammation directly but also provide food for beneficial bacteria like Akkermansia and Bifidobacteria. So, polyphenol consumption can promote gut colonization by these two crucial groups of bacteria.

According to studies, the anti-aging benefits of grape polyphenols increase the number of Akkermansia in the digestive tract. The small intestine also responded to the rise in Akkermansia by secreting more incretin hormone. Incretins are crucial for regulating energy expenditure, glucose homeostasis, and fullness.

It has also been shown that the polyphenols found in cranberries have anti-obesity, anti-insulin resistance, and anti-inflammatory effects; these properties make cranberry a popular health food.

Red apple peels contain a type of polyphenol called procyanidins, which has been shown in animal studies to reduce the risk of weight gain, inflammation, and liver damage caused by a high-fat, high-sugar diet. These benefits were traced back to changes in the microbiome, specifically to elevated levels of the probiotic Akkermansia.

What foods increase akkermansia muciniphila?

To be more specific, try incorporating items such as cranberries, grapes, black tea, and walnuts into your diet. Increasing your intake of food is the method that is considered to be superior. To be more specific, try incorporating items such as cranberries, grapes, black tea, and walnuts into your diet.

Probiotics/Postbiotics

Remember Akkermansia, Live

The potential health benefits of Akkermansia probiotics for humans, beyond those attributable to alterations in diet and lifestyle, are the focus of current research.

However, there is lack of research on the effects of Akkermansia probiotics in humans; there has been extensive research on their impact on animal models of diet-induced obesity.

Suppressing Akkermansia populations in rodent models of diet-induced obesity (DIO) leads to circumstances comparable to those reported in humans with DIO, such as systemic inflammation, arterial plaque, breakdown of the gut mucus layer, and insulin resistance.After four to eight weeks of treatment with an Akkermansia probiotic, Akkermansia levels in the feces of DIO mice have returned to normal without any other changes to the microbiome’s composition.

Reduced inflammation, smaller plaques, normalized plaque thickness, decreased body weight, and enhanced insulin sensitivity were also observed in these animals.

Dosing may be an essential factor when employing Akkermansia probiotics in the setting of obesity and metabolic dysfunction in humans, as these advantages were only evident with the higher dose probiotic.

Pendulum glucose control reviews

Customers who use Pendulum Glucose Control for metabolic health have reported numerous positive side effects, including but not limited to: decreased blood sugar spikes, decreased sugar cravings, weight loss, more energy, and better sleep. This supplement is GRAS (Generally Recognized As Safe).

Pendulum Glucose Control is probiotic medical food that is intended to assist in minimizing post-meal blood sugar increases and lowering A1c levels in persons with Type two diabetes who are taking metformin. This is in comparison to consuming a placebo.

Why is it so hard to find Akkermansia?

Because it is an anaerobic strain, Akkermansia is exceedingly difficult to find (like your gut).

Most other probiotics sold in stores can breathe oxygen, but not Akkermansia.

To date, methods have yet to be developed that would be suitable for the large-scale production of Akkermansia. Therefore, Pendulum enlisted the help of microbiologists to devise an oxygen-free manufacturing process that yields high yields of Akkermansia.

Pendulum’s innovative research has led to the release of Akkermansia muciniphila, a strain of beneficial bacteria that represents the next generation in the field.

Pendulum Glucose Control and Pendulum Akkermansia are the only supplements on the market that contain akkermansia. The enteric-coated capsule guarantees that the beneficial strains make it to your gut.

How To Increase Akkermansia? A Comprehensive Guide

How much is Akkermansia in Pendulum Glucose Control?

Each capsule of Pendulum Glucose Control contains 1 billion CFUs of Akkermansia, one of five probiotic strains.

How often should you take Pendulum Akermansia?

It is recommended to take Pendulum Glucose Control at breakfast and dinner twice daily. It is recommended to take Pendulum Akkermansia once daily with a meal.

Akkermansia overdose: dangerous?

The Chief Medical Officer at Pendulum Therapeutics, Orville Kolterman, MD, cites a study showing that Akkermansia levels are elevated in MS patients. Kolterman also notes that no studies involving the administration of more than 1 billion Akkermansia colony forming units (CFUs) per day to human subjects have been conducted.

Are there any side effects to Akkermansia?

Some people experience temporary gastrointestinal side effects upon starting PGC or Akkermansia. This is a common side effect of using any probiotic since they all alter the microbiome in some way.

Does Pendulum Akkermansia help people with Type 2 diabetes?

Type 2 diabetes is not treated with Pendulum Akkermansia.

In contrast, Pendulum Glucose Control has been shown to reduce A1C levels and post-meal blood-glucose spikes in people with Type 2 diabetes taking metformin. Thus, it may be a better option for those looking to help control their diabetes.

Pendulum Akkermansia is superior if you want to improve your gut health and your Akkermansia count.

Is it safe to use Akkermansia?

No. There is no requirement for premarket approval from the FDA for either food or medical food. Probiotics from Pendulum are GRAS, meaning they have been deemed safe for use in the intended context by a consensus of leading scientists.

Cross-feeding with bifidobacteria is recommended for Akkermansia.

Probiotics containing Bifidobacterium animalis (subspecies lactis) were administered to DIO rodents in other studies to determine whether boosting this species’s population in the gut would also increase the population of Akkermansia.

After being administered this species for 14 weeks, the amount of A. muciniphila in the feces of the animals increased dramatically. The probiotic-treated group gained less weight when both groups were fed a high-fat, high-sugar diet.

The researchers speculate that B. animalis may promote the development of A. muciniphila by increasing butyrate production, which stimulates the production of mucus in the gut.

Postbiotics Akkermansia

How exactly do postbiotics function? In addition to taking Akkermansia probiotics, there is a promising new application for Akkermansia postbiotics. A postbiotic is ingested after the bacteria have been killed or rendered inactive and is thus 

also known as ghost probiotic or para-probiotic.

Benefits

 Pasteurized Akkermansia postbiotic had even more beneficial effects than a live Akkermansia probiotic when given to healthy, normal mice in rodent models. There were more significant improvements in lipid profiles, glucose control, liver enzymes, and immune markers in mice that were given a postbiotic instead of a live probiotic.

Using a Postbiotic Has Its Advantages Considering the dangers of using live probiotics, such as the risk of irritable bowel syndrome (IBS) and infection in infants, the elderly, and those with compromised immune systems, the potential efficacy of postbiotics is highly encouraging.

FAQs

What should I give my Akkermansia to help it grow?

Eat more berries, tea, and nuts to improve your health. Indeed, dietary means are the best way to boost levels. Make room for your diet for cranberries, grapes, black tea, and walnuts.

How come Akkermansia is so weak? 

Type II diabetics, people with inflammatory bowel disease, and obese people tend to have lower levels of the microbe Akkermansia muciniphila. As one age, their Akkermansia muciniphila concentration naturally decreases.

What does Akkermansia eat?

For the benefit of other bacteria, it degrades mucins into short-chain fatty acids. Akkermansia muciniphila has been linked to improved insulin function, reduced chronic disease symptoms, and low inflammation.

What causes Akkermansia to be high?

Akkermansia may cause a leaky gut by devouring the intestinal mucosal layer, which may explain why it is more prevalent in people with certain autoimmune conditions (26).

Is it possible to have too much akkermansia?

However, if your Akkermansia levels are already ideal, you should avoid going overboard. Maintaining a healthy mucin barrier in the gut is essential, and an overabundance of Akkermansia can lead to its breakdown, exposing the mucosal lining.

Can I purchase Akkermansia?

Yes. The Pendulum Akkermansia is sold independently.