Intermittent fasting extends life – Time-Restricted Eating Changes Body Gene Expression.


Intermittent fasting extends life – Time-Restricted Eating Changes Body Gene Expression. According to research conducted by the Salk Institute, the timing of calorie intake has been shown to synchronize circadian rhythms in mice across various systems.

Research has demonstrated that time-restricted eating has positive health effects, including a longer lifespan in experimental settings. Methods like intermittent fasting have become widely discussed in health and fitness. It has yet to be understood how it impacts the organism on the molecular level and interacts as interact organ systems. Researchers at the Salk Institute have demonstrated that time-restricted feeding alters gene expression in more than 22 organ systems. When genes are expressed, they make proteins in response to their surroundings.

Cell Metabolism published the results on January 3, 2023; they have ramifications for various diseases and disorders where time-restricted eating has shown promise.

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According to Professor Satchidananda Panda, senior author and holder of the Rita and Richard Atkinson Chair in Molecular Nutrition at Salk, time-restricted eating in mice has a system-wide molecular impact. Our findings pave the way for further investigation into how this nutritional intervention activates genes related to several disorders, including cancer.

Two groups of mice were given the same high-calorie meal to test its effects. To one group, all meals were provided at no cost. The other group only had access to food for nine hours per day. After seven weeks, tissue samples were taken from the brain and 21 different organ systems to examine for genetic changes at various times of the day and night. Liver, stomach, lung, heart, adrenal gland, hypothalamus, kidney, intestine, and brain tissue samples were all collected.

The authors discovered that timed meal schedules affect 70% of mouse genes.

According to Panda, “by altering the timing of feeding, we were able to alter the gene expression of thousands of genes in the brain.”

Time-restricted eating altered about 40% of genes in the adrenal gland, brain, and pancreas. To regulate hormones, these organs play a crucial role. Many ailments, from diabetes to anxiety disorders, have been linked to hormonal imbalance because hormones coordinate the body’s and brain’s processes. Specific findings suggest that time-restricted eating could be helpful in the treatment and management of these conditions.

Notably, not every part of the digestive system was impacted. Time-restricted feeding induced gene expression in the duodenum and jejunum but not in the ileum, the terminal segment of the small intestine. These results suggest a new avenue for investigating the relationship between shift work and digestive disorders and cancers. Panda and colleagues have previously found that shift workers can benefit from time-restricted meals.

Time-restricted feeding synchronized the circadian cycles of several physiological systems, the researchers discovered.

Panda claims that “circadian rhythms are present in every single cell.” We discovered that fasting at specific times and eating at particular times of day synced the circadian rhythms to have two primary waves. This facilitates the body’s ability to coordinate many functions.

The next step for Panda’s group is to examine the impact of time-restricted eating on specific disorders or systems linked to the study, such as atherosclerosis, a hardening of the arteries that is a risk factor for cardiovascular disease and stroke, and chronic kidney disease.